St. Louis, United States → Chicago, United States · ✈ 1h 2min · 🚗 6h 51min
228 nautical miles · Time difference: Same timezone · Direction: northeast
The distance from St. Louis to Chicago is 422 km (262 miles). The fastest way to travel is by flight. A direct flight takes approximately 1h 2min.
The straight-line distance from St. Louis, United States to Chicago, United States is approximately 422 kilometers (262 miles or 228 nautical miles). This measurement uses the Haversine formula, computing the great-circle distance — the shortest path between two points on Earth's surface.
Chicago is located northeast of St. Louis. St. Louis is in North America, in the Midwest region of United States, while Chicago is in North America, in Midwest, United States. Both cities are in North America.
| Mode | Distance | Est. Time | Best For |
|---|---|---|---|
| ✈️ Flight | 422 km | ~1h 2min | Quick but may not save time with airport procedures |
| 🚗 Drive | ~549 km | ~6h 51min | Feasible with breaks |
| 🚂 Regular Train | ~506 km | ~4h 13min | Budget-friendly option |
Our recommendation: flight is typically the best way to travel from St. Louis to Chicago. At this distance, driving gives you the most flexibility and avoids airport overhead.
Based on an estimated road distance of 549 km, fuel costs for driving from St. Louis to Chicago are approximately $44–$82 USD (at $0.08–$0.15 per km, depending on vehicle efficiency and local fuel prices). Additional costs may include tolls, parking, and accommodation for longer trips.
St. Louis is a major city in United States with a population of approximately 301,578. Located in the Midwest region, it is an important hub in North America. Despite its smaller size, St. Louis plays an important regional role in United States and attracts visitors year-round.
Chicago is a notable city in United States with a population of approximately 2,693,976. Situated in the Midwest region, it serves as a key destination in North America. Chicago offers solid transport connections and a variety of arrival options as a major city in United States.
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422 km is a medium-distance route, similar to traveling across a mid-sized European country. A flight covers this distance quickly, but driving or rail travel remains feasible for those who prefer ground transport. For reference, New York to Chicago is about 1,150 km.
At 422 km, the St. Louis-Chicago route is about 1.1% of Earth's circumference. A commercial jet covers this distance in about 1h 2min.
At just 422 km within United States, the St. Louis–Chicago corridor is well-suited for a day trip or weekend getaway. Consider driving for flexibility, or check regional rail connections for a hassle-free journey.
The straight-line distance from St. Louis to Chicago is approximately 422 kilometers (262 miles, 228 nautical miles).
A direct flight takes approximately 1h 2min, based on 800 km/h cruising speed plus 30 minutes for takeoff and landing.
Estimated driving time is approximately 6h 51min, based on 80 km/h average speed and roads being ~30% longer than straight-line distance.
Chicago is approximately Same timezone compared to St. Louis.
The estimated road distance is approximately 549 km, which is about 30% longer than the 422 km straight-line distance.
📍 Data: Coordinates from OpenStreetMap contributors. Distances calculated using the Haversine formula. Travel times are estimates only. Last verified: April 7, 2026.